The solution of the outer multiplicity problem in the tensor product of U(3) irreducible representations (irreps) developed by Biedenharn et al.(1–7) and realized through the well-known Draayer-Akiyama (DA) computer code(8) is extended to the quantum algebra Uq(3). An analytic formula for special stretched Uq(3) Wigner coefficients, $$\left\langle {(\lambda _1 \mu _1 ) H_1 , (\lambda _2 \mu _2 ) \varepsilon _2 \Lambda _2 m_2 \left| { (\lambda _3 \mu _3 ) H_3 } \right.} \right\rangle _{\max }^q $$ is derived using (...) a projection operator method.(9–10) In this expression Hi denotes the highest weight vector of the (λiμi) irrep; the subscript “max” means coefficients corresponding to a unit tensor operator with a maximal characteristic null space; and q is the usual quantum label so the standard U(3) Wigner coefficient, which is required in the DA code, can be obtained in the q→1 limit of the theory. To illustrate the theory, some Uq(3) Wigner coefficients for the tensor product (22)×(22) are calculated. The procedure for evaluating nonhighest weight Wigner Uq(3) coefficients follow the DA prescription. (shrink)

From the very beginning it was realised that quantum physics involves radically new interpretative and epistemological consequences. While hitherto there has been no satisfactory philosophical analysis of these consequences, recent years have witnessed the accomplishment of many experiments to test the foundations of quantum physics, opening up vistas to a completely novel technology: quantum technology. The contributions in the present volume review the interpretative situation, analyze recent fundamental experiments, and discuss the implications of possible future technological applications. Readership: Analytic philosophers (...) (logical empiricists), scientists (especially physicists), historians of logic, mathematics and physics, philosophers of science, and advanced students and researchers in these fields. Can be used for seminars on theoretical and experimental physics and philosophy of science, and as supplementary reading at advanced undergraduate and graduate levels. (shrink)

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

As we approach the third millenium we ask what we want to bring forward from the past and what we wish to develop anew. Like planning to begin human life on ...

The most enigmatic feature of polytene chromosomes is their banding pattern, the genetic organization of which has been a very attractive puzzle for many years. Recent genome‐wide protein mapping efforts have produced a wealth of data for the chromosome proteins of Drosophila cells. Based on their specific protein composition, the chromosomes comprise two types of bands, as well as interbands. These differ in terms of time of replication and specific types of proteins. The interbands are characterized by their association with (...) “active” chromatin proteins, nucleosome remodeling, and origin recognition complexes, and so they have three functions: acting as binding sites for RNA pol II, initiation of replication and nucleosome remodeling of short fragments of DNA. The borders and organization of the same band and interband regions are largely identical, irrespective of the cell type studied. This demonstrates that the banding pattern is a universal principle of the organization of interphase polytene and non‐polytene chromosomes.Editor's suggested further reading in BioEssaysCaught in the act: Rapid, symbiont‐driven evolution AbstractFunction and evolution of sex determination mechanisms, genes and pathways in insects Abstract. (shrink)

Fear is a common and potentially distressful psychological response to the current COVID-19 pandemic. The factors associated with such fear remains relatively unstudied among older adults. We investigated if fear of COVID-19 could be associated with a combination of psychological factors such as anxiety and depressive symptoms, and risk perception of COVID-19, and demographic factors in a community sample of older adults. Older adults (N= 413,Mage= 69.09 years,SD= 5.45) completed measures of fear of COVID-19, anxiety and depressive symptoms, and risk (...) perception of COVID-19, during a COVID-19 lockdown. These variables, together with demographics, were fitted to a structural equation model. Anxiety and depressive symptoms were highly correlated with each other and were combined into the higher order latent variable of affective symptoms for analyses. The final model revealed that fear of COVID-19 was positively associated with psychological factors of affective symptoms and risk perception. Older age was associated with greater fear of COVID-19. Our findings showed that fear of COVID-19 can be a projection of pre-existing affective symptoms and inflated risk perceptions and highlighted the need to address the incorrect risk perceptions of COVID-19 and socio-affective issues among older adults in the community. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Ibn al-Bannāʼ, Aḥmad ibn Muḥammad, 1256?-1321?'s al-Rawḍ al-murīʻ fī ṣināʻat al-badīʻ; arabic language; rhetoric; criticism and interpretation.

The neural basis of progress monitoring has received relatively little attention compared to other sub-processes that are involved in goal directed behavior such as motor control and response inhibition. Studies of error-monitoring have identified the dorsal anterior cingulate cortex (dACC) as a structure that is sensitive to conflict detection, and triggers corrective action. However, monitoring goal progress involves monitoring correct as well as erroneous events over a period of time. In the present research, 20 healthy participants underwent fMRI while playing (...) a game that involved monitoring progress towards either a numerical or a visuo-spatial target. The findings confirmed the role of the dACC in detecting situations in which the current state may conflict with the desired state, but also revealed activations in the frontal and parietal regions, pointing to the involvement of processes such as attention and working memory in monitoring progress over time. In addition, activation of the cuneus was associated with monitoring progress towards a specific target presented in the visual modality. This is the first time that activation in this region has been linked to higher-order processing of goal-relevant information, rather than low-level anticipation of visual stimuli. Taken together, these findings identify the neural substrates involved in monitoring progress over time, and how these extend beyond activations observed in conflict and error monitoring. (shrink)

The dominant view of the Western intellectual tradition, or perhaps more accurately, the continental European tradition, emphasizes the primacy of the universal over the particular when it comes to understanding the nature of knowledge. This preoccupation with the universal is undernined by the theory o.f tacit knowing which underlines the mediation of the universal and the particular with an emphasis on the lafter, that is, the particular. An analysis of Kant’s notions of determinative and reflective judgment reveals that he grounds (...) each in tacit processes, privileging the role of particular examples or exemplars. Structural similarities between Kant’s judgments of taste and Polanyi’s notion of personal knowledge illuminates Polanyi’s surprising claim that “The very nature of knowledge is in the Third Critique, not in the First Critique.”. (shrink)

La Segunda consideration intempestiva delimita una relación funcional con la historia: esta beneficia a la vida cuando se posiciona desde una perspectiva ilusoria, disimulada y estratégica. Se analizan dos consecuencias: la crítica de la historia como ciencia objetiva y los matices que se desprenden de considerarla como relato. Si G. Agamben ha mostrado cómo la historia surge en el intersticio que hay entre lenguaje y discurso, el debate debe orientarse al proceso por el que la subjetividad adviene a un lenguaje (...) que debe "historizar". Esto implica explorar las relaciones entre felicidad e historia como depósito de sentido y de esperanza. The Second Untimely Meditation establishes a functional relation to history: the latter benefits life when it is considered from an illusory, dissimulated, and strategic perspective. The article analyzes two consequences of this: the critique of history as an objective science and the nuances entailed by considering it as a narrative. If G. Agamben has shown how history arises in the interstice between language and discourse, the debate should focus on the process through which subjectivity acquires a language that must be "historicized". This implies exploring the relations between happiness and history as a repository of meaning and hope. A Segunda consideração intempestiva delimita uma relação funcional com a história: esta beneficia a vida quando se posiciona a partir de uma perspectiva ilusória, disfarçada e estratégica. Analisam-se duas consequências: a crítica da história como ciência objetiva e as matizes que se desprendem de considerá-la como relato. Se G. Agamben tem mostrado como a história surge no interstício que há entre linguagem e discurso, o debate deve ser orientado ao processo pelo qual a subjetividade advém a uma linguagem que deve "historizar". Isso implica explorar as relações entre felicidade e história como depósito de sentido e de esperança. (shrink)

La Segunda consideración intempestiva delimita una relación funcional con la historia: esta beneficia a la vida cuando se posiciona desde una perspectiva ilusoria, disimulada y estratégica. Se analizan dos consecuencias: la crítica de la historia como ciencia objetiva y los matices que se desprenden de considerarla como relato. Si G. Agamben ha mostrado cómo la historia surge en el intersticio que hay entre lenguaje y discurso, el debate debe orientarse al proceso por el que la subjetividad adviene a un lenguaje (...) que debe “historizar”. Esto implica explorar las relaciones entre felicidad e historia como depósito de sentido y de esperanza. (shrink)

Guidelines for a model bride in Islam based on Islamic teachings; includes stories of six exemplary Muslim wives during Prophet Muhammad's time.

Objectives: The N2b is an event-related potential component thought to index higher-order executive function. While the impact of concussion on executive functioning is frequently discussed in the literature, limited research has been done on the role of N2b in evaluating executive functioning in patients with concussion. The aims of this review are to consolidate an understanding of the cognitive functions reflected by the N2b and to account for discrepancies in literature findings regarding the N2b and concussion.Methods: A scoping review was (...) conducted on studies that used the N2b to measure cognitive functioning in healthy control populations, as well as in people with concussions.Results: Sixty-six articles that met inclusion criteria demonstrated that the N2b effectively represents stimulus-response conflict management, response selection, and response inhibition. However, the 19 included articles investigating head injury found widely varied results: some studies found the amplitude of the N2b to be increased in the concussion group, while others found it to be decreased or unchanged.Conclusion: Based on the available evidence, differences in the amplitude of the N2b have been linked to response selection, conflict, and inhibition deficits in concussion. However, due to large variations in methodology across studies, findings about the directionality of this effect remain inconclusive. The results of this review suggest that future research should be conducted with greater standardization and consistency. (shrink)

Book reviewed in this article: Gays/Justice by Richard Mohr. Death:Beyond Whole‐Brain Criteria, edited by Richard M. Zaner. The Contraceptive Ethos:Reproductive Rights and Responsibilities Edited by S.F. Spicker, W.B. Bondeson, H.T. Englehardt, Jr., Dordrecht, Holland:D. Reidel. Made to Order:The Myth of Reproductive and Genetic Progress Edited by Patricial Spallone and Deborah Lynn Steinberg. Reproductive Technologies:Gender, Motherhood and Medicine Edited by Michele Stanworth. For the Patient's Good:The Restoration of Beneficence in Health Care by Edmund D. Pellegrino and David C. Thomasma. ‘The Physician (...) as Captain of the Ship:A Critical Reappraisal’, Philosophy and Medicine, vol. 29. Edited by Nancy M.P. King, Larry R. Churchill, and Alan W. Cross. (shrink)

In the article the mutual influence of folk theatre, Austrian Singspiel and Viennese opera in the genres of comic opera, operetta and drama performances involving music, singing and dancing is studied. The powerful influence of Italian and French opera schools, as well as the Italian Commedia Dell'arte led to the flourishing of music and theatre art in Austria: opera buffa (A. Salieri, Ch. W. Glück, J. Haydn, W. A. Mozart), fairy-tale comedies of F. Raimund and satirical dramas of Nestroy. Their (...) game-like nature finds its expression in musical turns, satirical songs and duets. Viennese dance operetta has absorbed the traditions of Viennese popular comedy and comic opera. Recitative, vocal music and folk dances were the key elements of operettas (J. Strauss junior, F. von Suppe, K. Millöcker, K. Zeller, F. Lehar). The music and the game in Austria are the results of theatralization of life: the life turns into something like art. Austrian culture, which is addressed directly to the human being and short of complex philosophical musings and speculative schemes, has genetically built-in playful, musical and theatrical basis, as well as German. Strongly-pronounced playful and musical source as an important national component of the culture, its code, determine its highly fictitious character (staginess) and integrity (both genre and intermediately), thereby maintain its special status in the European culture. (shrink)

This essay was contributed to the celebration of Father Mclean’s 75th birth day in a volume To the Mountain—essay in honor of Professor George F. Mclean (Fu Jen Catholic University Press, Taiwan, 2004.) In this essay I recalled what I knew of him by personal contact. As I wrote this essay, I was moved myself by his personality. Just as it says on the preface of the volume, “Over the past 40 years, George Mclean has helped to establish contacts and (...) build relations with philosophers in most of the countries of the world, and hundreds—indeed, thousands—of scholars are in his debt”, I am one of those hundreds, or thousands scholars in his debt. I am sure people may tell their own story about Professor George Mclean as they know themselves. (shrink)

The consistent tanh expansion method is successfully applied to the coupled integrable dispersionless system. A nonauto-Bäcklund transformation theorem includes two fields f and v 1 is obtained by using the CTE method. One obtains the consistent condition in the nonauto-BT theorem by means of the relation between the fields f and v 1. The CID system possesses the CTE solvability property by some detailed analysis. Many interactions between one soliton and multiple resonant solitons, and between one soliton and cnoidal waves (...) are generated by using the nonauto-BT theorem. The types of bright and gray two front waves are shown by some figures. In the meanwhile, the nonlocal symmetry is obtained by the truncated Painlevé method and the Möbious invariant form. The initial value problem and an auto-BT are constructed by the localization procedure. (shrink)

In this paper we prove that the preordering $\lesssim $ of provable implication over any recursively enumerable theory $T$ containing a modicum of arithmetic is uniformly dense. This means that we can find a recursive extensional density function $F$ for $\lesssim $. A recursive function $F$ is a density function if it computes, for $A$ and $B$ with $A\lnsim B$, an element $C$ such that $A\lnsim C\lnsim B$. The function is extensional if it preserves $T$-provable equivalence. Secondly, we prove a (...) general result that implies that, for extensions of elementary arithmetic, the ordering $\lesssim $ restricted to $\Sigma_{n}$-sentences is uniformly dense. In the last section we provide historical notes and background material. (shrink)

The study is devoted to the study of actual state of the archival materials of V.S. Solovyov which are held in different funds of Russia. During the working process was carried out the analysis of Solovyov’s related materials in a number of archives of Moscow and St. Petersburg. In the context of this topic, documents from such archive funds as: RGALI, GARF, TsAGM, OR RSL (Moscow), OR RNL, IRLI RAS, RGIA (St. Petersburg) were reviewed. Particular attention was paid to the (...) 1880s as the least researched period of philosopher’s work in his biography due to the insufficient availability of sources and to the restrictions of spiritual censorship in connection with the church-political content of Solovyov’s works of this period (“The Great Debate and Christian Politics”, 1883; “The History and Future of Theocracy”, 1887, etc.). In this regard, special attention was paid to the Solovyov funds in such archives as RGALI (F. 446) and OR RNB (F. 718). In the course of the study, many storage units were identified containing unsorted, draft materials, notebooks and notes of the philosopher, which need to be systematized and studied. The work carried out allows us to establish the scale and determine the priority areas of current research on the creative biography and philosophy of V.S. Solovyov based on the study of primary sources in the archives of Russia. (shrink)

The relevance of the article is due to the authors attempt to apply some of the philosophical concepts of F.M. Dostoevsky to the comprehension of contemporary sociocultural reality. The purpose of this study is to clarify the reasons for the historically unfriendly attitude of Europe towards Russia by analyzing the works of F.M. Dostoevsky dedicated to this problem. In the process of writing the article, the published Diaries of the writer were used; diary entries unpublished during the writer's life; philosophical (...) reflections contained in works of art, as well as applied modern scientific and popular science literature dedicated to the work of F.M. Dostoevsky. In the course of the analysis, it was found that the writer considered historical, confessional and moral reasons to be the main factors in the rejection of Russia by Europe, while he especially singled out disinterestedness incomprehensible to Europe as a characteristic of the Russian people. The authors draws attention to the fact that all the reasons for Europe's "remarkable dislike" for Russia, about which F.M. Dostoevsky, directly or indirectly associated with the Orthodox faith. Therefore, an attempt to actualize the worldview heritage of the great writer will certainly lead us to a dilemma: either to move from thoughts and words to actions, to religiously enlighten both ourselves and Europe; or to enclose our Orthodox heritage in a historical and cultural framework, eliminating the source of the reasons for our rejection by the European public, with all the ensuing consequences. (shrink)

In this paper we investigate conditions for Lp-computability which are in accordance with the classical Grzegorczyk notion of computability for a continuous function. For a given computable real number p ≥ 1 and a compact computable rectangle I ⊂ ℝq, we show that an Lp function f ∈ Lp is LP-computable if and only if f is sequentially computable as a linear functional and the Lp-modulus function of f is effectively continuous at the origin of ℝq.

We show that a computable function $f:\mathbb R\rightarrow \mathbb R$ has Luzin’s property if and only if it reflects $\Pi ^1_1$ -randomness, if and only if it reflects $\Delta ^1_1$ -randomness, and if and only if it reflects ${\mathcal {O}}$ -Kurtz randomness, but reflecting Martin–Löf randomness or weak-2-randomness does not suffice. Here a function f is said to reflect a randomness notion R if whenever $f$ is R-random, then x is R-random as well. If additionally f is known to have (...) bounded variation, then we show f has Luzin’s if and only if it reflects weak-2-randomness, and if and only if it reflects $\emptyset '$ -Kurtz randomness. This links classical real analysis with algorithmic randomness. (shrink)

The article is devoted to the problem of time in modern science, where in recent years there have been major changes related to the latest discoveries in the field of the foundations of quantum theory. The author refers to works of K.-F. von Weizsacker (which works are not well-known in Russian-speaking field). Weizsacker deploys a large-scale program of building modern physics, while starting (not only as a physicist, but also a professional philosopher) with questions of philosophical interpretation of postulates of (...) modern physics, especially quantum mechanics. His key thesis is that time in physics is fundamentally distinct, which represents the whole physics as an integral scientific discipline. Weizsacker comes from physical and philosophical reflections, that give a special value to his work. Analyzing the conclusions of theoretical physics, namely the issues of substantiation of statistical mechanics, thermodynamics, and, above all, quantum mechanics, Weizsacker comes to the key idea of the structure of time in the substantiation of physical theory. The author in this conclusion disagrees with the opinion of most modern physicists that time has a subjective character, and the modus of the past, present and future reflects its essential character. The allocation of the time structure requires special logic. Such a logic is temporal and quantum. Starting from temporal logic, introducing the concept of possibility and probability, he comes to the substantiation of quantum mechanics. Being modal logic, it is based on the concept of possibility and probability. Key concept for Weizsacker is a binary alternative (Uralternative), closely related to the principle of superposition in quantum mechanics. By introducing the concept of certain alternatives, essentially actualized alternatives, Weizsacker shows how one can get the theory of relativity with its space-time structure. Further, he shows that based on its structure, you can get the theory of relativity. The space-time structure in this case is secondary, relational, as understood by Leibniz, Mach, and Einstein. (shrink)

Religious life Islam; Religious life Shīʻah.

Abū al-Ḥajj¿j Yūsuf b. Muḥammad Ibn Ṭumlūs (Alhagiag Bin Thalmus, d. 620/1223) was a philosopher, physician and direct disciple of Ibn Rushd (Averroes, d. 595/1198), who lived and practiced rational sciences in Alzira and Marrakesh, a quarter of a century after the demise of his teacher. Ibn Ṭumlūs was not Ibn Rushd's only student who engaged in work on logic, but one of dozens of disciples, suggesting that the supposed simultaneous death of the latter's philosophy is "grossly exaggerated". As a (...) valuable window into the practice of logic in 13th century al-Andalus and the Maghreb, Ibn Ṭumlūs' Compendium on Logic (Al-Mukhtaṣar fī al-manṭiq) covers all the parts of "the expanded Organon", as it was known since al-F¿r¿bī (d. 339/951). The present volume offers a complete critical Arabic edition of this work, with an English and Arabic introduction, notes and indices. (shrink)

Twenty classes in ten schools with 627 sixth?grade students in five cities in Taiwan participated in this study. The research provides information on the performance differences among written computation, pictorial representation, symbolic representation and number sense. The results of One?way ANOVA analysis indicate that significant difference was found among WCT, PRT, SRT and NST tests, with F=536.327, p=0.000. The a posteriori comparisons show for each pair (WCT vs PRT, WCT vs SRT, WCT vs NST, PRT vs SRT and SRT vs (...) NST) significant difference at the 0.001 level (p=0.000), except for the pair comparison between PRT and NST. This implies that these Taiwanese students were highly skilled in written computation but their written skills were not equally transferred to use of non?computational paths that depended on symbolic representation, pictorial representation and number sense to solve similar problems. (shrink)

On the Islamic concept of evolution and progress; historical and philosophical study.